Inducing senescence or apoptosis
Rationale: Targeting telomerase activity limits the ability of cancer cells to maintain their telomeres, directly affecting the hallmark of “Enabling replicative immortality.” Without functional telomerase, cancer cells are more likely to undergo senescence or apoptosis due to critically short telomeres.
Q7 A cancer patient’s tumour is found to have a mutation that activates the PI3K-AKT signalling pathway. Which of the following hallmarks is most directly promoted by this mutation, and why? (note PI3K does lots of things, what is most relevant here)
LaNts and Laminins 