TTG end

That last question was tricky, but you identified the transcription factor as one that might benefit.

This sort of question needs lots of contextual information to explain fully. However, very quickly, both the keratin and the beta-globin proteins require multimeric structures to be functional (filaments of haemoglobin respectively). Expressing a little part of the protein would disrupt the healthy protein, so its actually better to have no mutant protein. Indeed, missense mutant keratins of beta-globins have dominant inheritance patterns, whereas PTCs are recessively inherited. However, for the transcription factor, the effects are usually a dose-dependent. The diseases are often “haploinsufficient”, half is not enough. Therefore a little bit more, even if not 100% perfect might help. Many transcription factors dimerise for activity, and, of course, which part of the protein is missing will determine whether a treatment might work. But, based on the options available, the transcription factor was most likely. This paper is really good if you want to learn more.

You’ve reached the end of this quiz, well done! I hope you have enjoyed and/or learned something. Want to try some more quizzes?